All Medications are given together under directly observed therapy (DOT). Medications are administered seven (7) days per week for at least the first two weeks of therapy. Then medications may be administered five (5) days per week by DOT, with the remaining two doses self-administered over the weekend. Medications for those expected to gain weight during therapy are written as mg/kg; the nurse will weigh the person weekly and drug dosage will be adjusted to maintain the mg/kg dose as closely as possible. Adjustments to dose, frequency, and duration of therapy are common and depending upon the patient’s disease and response to therapy. For the purpose of this document, adult dosing begins at age 15 years or at weight of > 40 kg in younger children